Monitoring during therapy: anti-factor Xa activity can be assessed in specific cases not generally recommended.Drugs: enoxaparin, dalteparin, tinzaparin, nadroparin, certoparin.In order to detect heparin-induced thrombocytopenia, platelets must be continuously monitored during heparin therapy and a baseline should be established before commencing treatment. Antidote : : protamine sulfate (a positively-charged protein that can neutralize negatively-charged heparin by forming inactive complexes).Clearance: hepatic (preferred agent for patients with renal insufficiency ).Monitoring during therapy : : activated partial thromboplastin time ( aPTT ), platelet count (including baseline before treatment is started).
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